MC-Gly-Gly-Phe-Gly-PAB(m-PEG4) oregon green Fitzgibbons

Fitzgibbons

Induced degradation of SNAP-fusion proteins

NCT02 is a molecular glue cyclin K degrader

It is preferred for some complicated biological applications where reproducibility is more critical than material cost since the minor positional difference between 5-ROX and 6-ROX might significantly affect some biological properties of the underlying conjugates

VHL-SNAP2-5C is a SNAP PROteolysis TArgeting Chimera (SNAP-PROTAC)

MC-Gly-Gly-Phe-Gly-PAB(m-PEG4) oregon green FitzgibbonsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be